NYSCF's latest paper could have important implications for human reproductive technologies. The scientists showed proof of principle that genome transfer can rescue developmentally incompetent eggs, making them viable for use in reproduction. NYSCF Research Institute scientist Dr. Mitsutoshi Yamada and NYSCF – Robertson Investigator Dr. Dieter Egli used a mouse model to investigate the causes of the decline in developmental potential in aged oocytes.
Through a battery of complementary experiments transferring the genomes of differently aged mouse oocytes post ovulation, the scientists showed that the developmental decline in oocytes is primarily due to abnormal function of cytoplasmic factors, not to deterioration of the genome. This research was published in Stem Cell Reports.