NYSCF in the News

The New York Times Magazine featured NYSCF’s cutting-edge research and our efforts to bring to patients our technique of preventing the transmission from mother to child of mitochondrial diseases as a cover story. The technique, pioneered and developed at the NYSCF Research Institute lead by NYSCF scientist Dr. Dieter Egli and his colleagues, involves transferring into a donor egg the nucleus of an egg cell from a woman affected by or with a family history of mitochondrial diseases. This would allow her to have a genetically related child that would be unaffected by this group of diseases. Dr. Egli presented this work to an FDA advisory committee earlier this spring in an important first step toward bringing this technique to patients.

There are currently no cures for this group of devastating diseases. Mitochondrial disorders affect approximately 1 in 10,000 people, while nearly 1 in 200 individuals carry mutant mitochondria. Symptoms, which most often appear in childhood, may include stunted growth, kidney disease, muscle weakness, neurological disorders, loss of vision and hearing, and respiratory problems, among others.

Our experiments have demonstrated the efficacy and safety of this technique, making NYSCF and our clinical collaborators at Columbia University the leading candidate to bring this technique to human clinical trials in the United States. 

 

Read the story in The New York Times Magazine >>

NYSCF – Robertson Neuroscience Investigator Dr. Ed Boyden of MIT Media Lab, published his latest research in Nature Methods on a new platform to study electrophysiology in cells using an all-optical method. This platform, called Optopatch, is built from a handful of engineered markers and vectors and enables high-throughput, spatially resolved electrophysiology without the use of traditional electrodes, opening new vistas for neuroscience research.  

 

Read the paper in Nature Methods >>

NYSCF - Robertson Stem Cell Investigator Dr. Paul Tesar of Case Western Reserve University School of Medicine published a paper in Cell Stem Cell describing 'seeds' of stem cells' development. The scientists discovered landmarks within pluripotent stem cells that guide how they develop and become different types of cells in the body. 

This research has huge implications, potentially allowing future scientists to understand and direct stem cell differentiation to prevent and cure disease and injury. 

 

Read the paper in Cell Stem Cell >>

Read more in Genetic Engineering & Biotechnology News >>

NYSCF welcomed the 2014 class of NYSCF - Druckenmiller Postdoctoral Fellows at a reception at the Asia Society. These seven exceptional scientists work in stem cell research areas from cancer development to understanding diseases such as Alzheimer's and multiple sclerosis and will continue to add to the success and prestige of the program. As the future scientific leaders of tomorrow, NYSCF is more than happy to welcome them into the NYSCF community. 

The new fellows are: 

- Dr. Zhongwei Cao, who will be working on understanding why lymphoma cells are resistant to chemotherapy at Weill Cornell Medical College.

- Dr. Panos Douvaras, who will be working on understanding multiple sclerosis using patient-specific cells at the New York Stem Cell Foundation Research Institute.

- Dr. Alexandre Gaspar Maia, who will be working on understanding cellular reprogramming and cancer progression at the Icahn School of Medicine at Mount Sinai.

- Dr. Bjarki Johannesson, who will be using stem cells to understand type 1 diabetes at the New York Stem Cell Foundation Research Institute.

- Dr. Maltane Ortiz-Virumbrales, who will be exploring effective personalized treatments for Alzheimer’s disease at the Icahn School of Medicine at Mount Sinai.

- Dr. Dominik Paquet, who will be working on understanding the molecular mechanisms of nerve cell degeneration in Alzheimer’s disease at The Rockefeller University.

- Dr. Maria Themeli, who will be using stem cells to generate cancer fighting T cells at Memorial Sloan-Kettering Cancer Center. 

 

Learn more about the 2014 Fellows here >> 

Wednesday, 28 May 2014 12:30

NYSCF Speaks at London Meetings

A team of NYSCF scientists and staff spoke about NYSCF and NYSCF's research programs at key meetings in London, England. NYSCF CEO Susan L. Solomon and NYSCF Investigators Dr. Scott Noggle and Dr. Danny Freytes presented NYSCF's latest research at a aspecial seminar at King's College London, the London Regenerative Medicine Network meeting, and at the World Stem Cells and Regenerative Medicine Congress. 

These meetings brought together various key stakeholders in the stem cell community from the UK and all around the world to discuss the stem cell field and report on new research discoveries. 

 

Read more about the London Regenerative Medicine Network Meeting >>

Read more about the World Stem Cells and Regenerative Medicine Congress >>

Wednesday, 28 May 2014 10:59

Scientists Improve Neuron Imaging

NYSCF - Robertson Neuroscience Investogator Dr. Ed Boyden of MIT Media Lab described his lab's latest neuron imaging breakthrough in Nature Methods. The research describes the ability of the scientists to image, for the first time, the entire nervous system (all the neurons firing) in a worm and zebrafish larva in three dimensions, in the whole animal. This achievement shows how signals move throughout the animals in real time. 

This technique will allow scientists to map how individual neurons respond to certain stimuli, ultimately, with a goal to image mammalian brains in the same way. 

 

Read more in MIT News >>

Read more in the Huffington Post >>

Read the paper in Nature Methods >>

NYSCF - Druckenmiller Fellow Dr. Sandra Pinho of Albert Einstein College of Medicine published her latest research on bone marrow development. The research, published in Developmental Cell, helps demystify bone marrow development by tracking a specific gene expression, Osterix, through three waves of progney cells. 

Bone marrow development is not well understood, therefore this research helps identify how developing bone marrow is organized with implications for tissue regeneration after injury and blood and bone diseases. 

 

Read the paper in Developmental Cell >>

Scientists identified a stem cell progney, called Transit-Amplifying Cells or TACs, play a key role in telling hair follicle stem cells when to become active. NYSCF - Druckenmiller Fellow Dr. Ya-Chieh Hsu of The Rockefeller University was first author on the paper, published in Cell.

While the specific signals may differ, TACs are found in many different adult tissues, making this research important for understanding stem cell function in the intestines and blood, among other tissues. 

 

Read more in The Rockefeller Universtiy Newswire >>

Read the paper in Cell >>

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