NYSCF - Robertson Stem Cell Investigator Dr. Paul Tesar of Case Western Reserve University School of Medicine published a paper in Cell Stem Cell describing 'seeds' of stem cells' development. The scientists discovered landmarks within pluripotent stem cells that guide how they develop and become different types of cells in the body.
This research has huge implications, potentially allowing future scientists to understand and direct stem cell differentiation to prevent and cure disease and injury.
NYSCF welcomed the 2014 class of NYSCF - Druckenmiller Postdoctoral Fellows at a reception at the Asia Society. These seven exceptional scientists work in stem cell research areas from cancer development to understanding diseases such as Alzheimer's and multiple sclerosis and will continue to add to the success and prestige of the program. As the future scientific leaders of tomorrow, NYSCF is more than happy to welcome them into the NYSCF community.
The new fellows are:
- Dr. Zhongwei Cao, who will be working on understanding why lymphoma cells are resistant to chemotherapy at Weill Cornell Medical College.
- Dr. Panos Douvaras, who will be working on understanding multiple sclerosis using patient-specific cells at the New York Stem Cell Foundation Research Institute.
- Dr. Alexandre Gaspar Maia, who will be working on understanding cellular reprogramming and cancer progression at the Icahn School of Medicine at Mount Sinai.
- Dr. Bjarki Johannesson, who will be using stem cells to understand type 1 diabetes at the New York Stem Cell Foundation Research Institute.
- Dr. Maltane Ortiz-Virumbrales, who will be exploring effective personalized treatments for Alzheimer’s disease at the Icahn School of Medicine at Mount Sinai.
- Dr. Dominik Paquet, who will be working on understanding the molecular mechanisms of nerve cell degeneration in Alzheimer’s disease at The Rockefeller University.
- Dr. Maria Themeli, who will be using stem cells to generate cancer fighting T cells at Memorial Sloan-Kettering Cancer Center.
A team of NYSCF scientists and staff spoke about NYSCF and NYSCF's research programs at key meetings in London, England. NYSCF CEO Susan L. Solomon and NYSCF Investigators Dr. Scott Noggle and Dr. Danny Freytes presented NYSCF's latest research at a aspecial seminar at King's College London, the London Regenerative Medicine Network meeting, and at the World Stem Cells and Regenerative Medicine Congress.
These meetings brought together various key stakeholders in the stem cell community from the UK and all around the world to discuss the stem cell field and report on new research discoveries.
NYSCF - Robertson Neuroscience Investogator Dr. Ed Boyden of MIT Media Lab described his lab's latest neuron imaging breakthrough in Nature Methods. The research describes the ability of the scientists to image, for the first time, the entire nervous system (all the neurons firing) in a worm and zebrafish larva in three dimensions, in the whole animal. This achievement shows how signals move throughout the animals in real time.
This technique will allow scientists to map how individual neurons respond to certain stimuli, ultimately, with a goal to image mammalian brains in the same way.
NYSCF - Druckenmiller Fellow Dr. Sandra Pinho of Albert Einstein College of Medicine published her latest research on bone marrow development. The research, published in Developmental Cell, helps demystify bone marrow development by tracking a specific gene expression, Osterix, through three waves of progney cells.
Bone marrow development is not well understood, therefore this research helps identify how developing bone marrow is organized with implications for tissue regeneration after injury and blood and bone diseases.
Scientists identified a stem cell progney, called Transit-Amplifying Cells or TACs, play a key role in telling hair follicle stem cells when to become active. NYSCF - Druckenmiller Fellow Dr. Ya-Chieh Hsu of The Rockefeller University was first author on the paper, published in Cell.
While the specific signals may differ, TACs are found in many different adult tissues, making this research important for understanding stem cell function in the intestines and blood, among other tissues.
2013 NYSCF - Robertson Prize winner Dr. Amy Wagers and NYSCF Scientific Advisor Dr. Lee Rubin, both of Harvard University, published on their latest breakthrough in muscle and blood stem cell research. The team of scientists published two papers in Science, describing the ability of a protein, GDF11 - previously shown to make the aging hearts of mice appear more like those of younger and healthier mice - also improved brain and skeletal muscle function in aging mice.
The research showed that injections of GDF11 increased the exercise capacity of aging mice as well as improved function in the olfactory area of their brains. This research has vast implications for new treatments and even cures for brain, blood and muscle disorders. The scientists expect human trials with GDF11 to begin in three to five years.
NYSCF - Robertson Neuroscience Investigator Dr. Takaki Komiyama of the University of California, San Diego, published the latest work from his lab on motor learning. The research, published in Nature, describes the scientists' discovery that the motor cortex, a part of the brain long known to control motor actions, actually plays an active role in learning new motor movements.
This research could lead to new approaches for the treatment of learning and movement disorders, including Parkinson's disease.