NYSCF in the News

The National Institute of Health (NIH) invited Susan Solomon to chair and moderate a panel at September’s NIH Workshop on Reproducibility in Cell Culture Studies. The panel, within the “Emerging Challenges and Opportunities” session of the workshop focused on the difficulties of stem cells and engineered environments. Solomon explored the challenges of modeling diseases in a dish and approaches that NYSCF has taken to develop reproducible stem cell culture studies. Among conversations about guidelines for stem cell production and maintenance, genetic diversity represented by stem cells, and current biotechnology, the panel discussed how the NYSCF Global Stem Cell ArrayTM responds to the issues of reproducibility in the field by automating the production of stem cells to reduce human error and standardize the production of stem cells, increasing reproducibility of stem cell research. Dr. Scott Noggle, NYSCF Vice President of Stem Cell Research also participated on several other panels discussing various issues related to cell culture reproducibility.


Read more about the workshop >>


The MacArthur Foundation named Dr. Lorenz Studer a 2015 MacArthur Fellow. A Founding member of NYSCF’s Medical Advisory Board, Dr. Studer served on inaugural juries of NYSCF Innovator postdoctoral fellows program and NYSCF-Robertson Investigator programs. Additionally, three NYSCF-Druckenmiller Fellows have trained in Dr. Stuber's lab. He has helped shape the future of stem cell research—guiding and granting early career scientists awards for their efforts and potential, while pushing forward with the most innovative research. As a MacArthur ‘Genius’ Dr. Studer’s incredible work lifts the entire field of stem cell research bringing international attention and support toward realizing the potential of regenerative medicine. 
Dr. Studer’s research focuses on neurodegenerative diseases such as ALS and Parkinson’s. He takes advantage of human pluripotent stem cells to make neurons to model and treat these deleterious diseases in his laboratory. His research is concerned with directing pluripotent cells to differentiate and mature into specific types of neuronal cells. In this pursuit, he has discovered how to speed up the aging process of cells so his lab can study neurons at the age most relevant to disease and potential drug discovery. Currently, he is preparing for clinical trials to transplant lab-made dopaminergic neurons, brain cells lost in Parkinson’s disease, into the brains of Parkinson’s patients. He will moderate a panel at NYSCF’s Tenth Annual Translation Stem Cell Research Conference in October.
Photo Credit: John D. & Catherine T. MacArthur Foundation.
NYSCF Vice President of Stem Cell Research, Dr. Scott Noggle leads The Stem Cell Podcast through a behind-the-scenes view of NYSCF’s one-of-a-kind robotic technology that creates hundreds of stem cells in tandem. On Episode 53 of the Podcast, hosts Dr. Christopher Fasano and Dr. Yosif Ganat interview Dr. Noggle about the ins and outs of the NYSCF Global Stem Cell ArrayTM and discover some of the details about how this pioneering technology was refined to generate consistent and efficient reprogramming of patients’ cells.
Dr. Noggle speaks on the power of stems cells to “probe into individuals’ biology in the laboratory” and discusses the research needs the Array was developed to respond to. On the horizon, Dr. Noggle looks forward to the power of populations of patient-specific stem cells generated by the Array to act as platforms for testing, developing, and finding new uses for drugs.

Dr. Gary Gibson, Director of the Laboratory for Mitochondrial Biology and Metabolic Dysfunction in Neurodegeneration at Weill Cornell Medical College, joined NYSCF as a visiting scientist while on sabbatical this year. Dr. Gibson’s work focuses on age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The Wall Street Journal highlighted his recent research, which finds a connection between vitamin B1 deficits and Alzheimer’s disease.

This work is currently being tested in a clinical trial, administering a synthetic version of vitamin B1 to Alzheimer’s patients and analyzing the results. At NYSCF he will translate his work to stem cells to further elucidate the mechanisms of neurodegeneration.


Read more in the Wall Street Journal >>

NYSCF and the Korea Health Industry Development Institute (KHIDI) of the Republic of Korea held a ceremony to officially sign a five-year memorandum of understanding, or MOU, setting the stage for future collaborations in the areas of health care and medical science as they relate to stem cell research. This agreement will promote collaboration and development as well as exchange of information between KHIDI and NYSCF, and, more broadly, between the United States and Korea, accelerating stem cell research and cures on an international scale.  

NYSCF - Robertson Neuroscience Investigator Dr. Gaby Maimon, The Rockefeller University, published his latest work studying visuomotor processing in fruit flies. The research, published in Nature Neuroscience, describes cellular and electrophysiological evidence that supports the theory that flies use active neural-circuit mechanisms to supress the perception of motion while flying. In addition, the scientists showed that these results mirror the visual supression of movement during rapid eye movement in primates.

Understanding neural image processing in animal models may lead to breakthoughs in our understanding of human visuomotor processing including pathologies related to visuomotor circuits. 


Read the paper in Nature Neuroscience >>

NYSCF - Robertson Stem Cell Investigator Dr. Alex Meissner, Harvard University, published his latest work studying the development and interaction of binding factors in mouse stem cells. This research, published in Cell Stem Cell, studies how 'ground state' conditions affect pluripotency factor binding using two pathway inhibitors. 

Understanding the specific steps and factors contributing to cell pluripotency is a necessary step in order to eventually develop successful future cell replacement treatments and therapies. 


Read the paper in Cell Stem Cell >>

NYSCF - Robertson Neuroscience Investigator Dr. Christopher Gregg, University of Utah, published his latest work on parental genetic imprinting in mice. The research, published in Cell Reports, describes how so-called noncanonical imprinting, meaning targeted and subtle unequal genetic imprinting, is prevalent in the brains of mice and skews the genetic message in subpopulations of cells leading to either the father or mother's genes having a larger, disproportionate say. The researchers showed this mechanism can influence behavior and appears to be preferred as compared to classic imprinting.

This work studies the influence of genetics at the cellular level, as compared to the level of the whole animal, and may lead to insights into neural behavior and disorders, such as autism. 


Read more in Science Codex >>

Read the paper in Cell Reports >>

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