NYSCF – Robertson Investigator Works to Understand Stem Cell Transdifferentiation
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NYSCF – Robertson Stem Cell Investigator Dr. Jacob Hanna, Weizmann Institute of Science, tested an alternate method of stem cell transdifferentiation – the process of a somatic cell turning into other cell types without passing through a pluripotent state – showing that the vast majority of reprogrammed mouse heart and brain stem cells created using this method did, in fact, briefly pass through a pluripotent state.
These findings, published in Nature Biotechnology, underscore the importance of understanding the steps and phases during cell reprogramming using different methods.