Proteins Reprogram Cells to Pluripotent State

An alternative method to achieve cellular pluripotency, Stanford University School of Medicine researchers led by John Cooke, MD, PhD, uncovered an efficient way to reprogram cells using cell permeant proteins, eliminating need for a viral vector. The researchers posit a process of “transflammation” prompts the cell to make its genetic material available when an immune response is elicited, which also makes it vulnerable to changes that render the cell pluripotent. This study is published in Cell.

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