Publications

2024

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis
Benjamin L.L. Clayton, Lilianne Barbar, Maria Sapar, Kriti Kalpana, Chandrika Rao, Bianca Migliori, Tomasz Rusielewicz, The NYSCF Global Stem Cell Array® Team, Daniel Paull, Katie Brenner, Dorota Moroziewicz, Ilana Katz Sand, Patrizia Casaccia, Paul J. Tesar, Valentina Fossati. Cell Stem Cell. 2024. DOI: https://doi.org/10.1016/j.stem.2024.08.002

Generating Neuroimmune Assembloids Using Human Induced Pluripotent Stem Cell (iPSC)-Derived Cortical Organoids and Microglia
Kalpana, K., Rao, C., Semrau, S., Zhang, B., Noggle, S., Fossati, V. Methods in Molecular Biology. 2024. DOI: https://doi.org/10.1007/7651_2024_554

Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers
Hannah A. Pizzato, Paula Alonso-Guallart, James Woods, Jon P. Connelly, Todd A. Fehniger, John P. Atkinson, Shondra M. Pruett-Miller, Frederick J. Monsma Jr., Deepta Bhattacharya. Stem Cell Reports. 2024. DOI: https://doi.org/10.1016/j.stemcr.2023.12.003

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Aleksandra Gladych-Macioszek, Agnieszka Klupczynska-Gabryszak, Teagan Polotaye, Michael Greenberg, Douglas Kung, Emily Hyde, Sarah Alshehri, Tonja Pavlovic, William Sullivan, Szymon Plewa, Helin Vakifahmetoglu-Norberg, Frederick J. Monsma, Jr., Patricia A. J. Muller, Jan Matysiak, Mikołaj Piotr Zaborowski, Analisa DiFeo, Erik Norberg, Laura A. Martin* and Marcin Iwanicki*. Nutrients. 2024. DOI: https://doi.org/10.3390/nu16121816 

2023

Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human
Priya Prakash, Hediye Erdjument-Bromage, Michael R. O’Dea, Christy N. Munson, David Labib, Valentina Fossati, Thomas A. Neubert, Shane A. Liddelow. Glia. 2023. DOI: https://doi.org/10.1002/glia.24494

Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Paul W Frazel, David Labib, Theodore Fisher, Ran Brosh, Nicolette Pirianian, Anne Marchildon, Jef D Boeke, Valentina Fossati, Shane A Liddelow. Nature Neuroscience. 2023. DOI: https://doi.org/10.1038/s41593-023-01424-2

FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines
Jeff Winchell, Gabriel Comolet, Geoff Buckley-Herd, Dillion Hutson, Neeloy Bose, Daniel Paull, Bianca Migliori. SLAS Discov. 2023. DOI: https://doi.org/10.1016/j.slasd.2023.08.004 (bioRxiv preprint 2023 Jul)

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis
Benjamin L. L. Clayton, Lilianne Barbar, Maria Sapar, Tomasz Rusielewicz, Kriti Kalpana, Bianca Migliori, The NYSCF Global Stem Cell Array, Daniel Paull, Katie Brenner, Dorota Moroziewicz, Ilana Katz Sand, Patrizia Casaccia, Paul J. Tesar, Valentina Fossati. bioRxiv. 2023. DOI: https://doi.org/10.1101/2023.08.01.551553

ScaleFExSM: a lightweight and scalable method to extract fixed features from single cells in high-content imaging screens
Bianca Migliori, Neeloy Bose, Daniel Paull. bioRxiv. 2023. DOI: https://doi.org/10.1101/2023.07.06.547985

Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)
Guang Lin, Burak Tepe, Geoff McGrane, Regine C Tipon, Gist Croft, Leena Panwala, Amanda Hope, Agnes JH Liang, Zhongyuan Zuo, Seul Kee Byeon, Lily Wang, Akhilesh Pandey, Hugo J Bellen. eLife. 2023. DOI: https://doi.org/10.7554/eLife.82555

2022

Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Carina Seah, Michael S. Breen, Tom Rusielewicz, Heather N. Bader, Changxin Xu, Christopher J. Hunter, Barry McCarthy, PJ Michael Deans, Mitali Chattopadhyay, Frank Desarnaud, Iouri Makotkine, Janine D. Flory, Linda M. Bierer, Migle Staniskyte, NYSCF Global Array Team, Scott A. Noggle, Laura M. Huckins, Daniel Paull, Kristen J. Brennand, Rachel Yehuda. Nature Neuroscience. 2022. DOI: https://www.nature.com/articles/s41593-022-01161-y 

Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness
Kirstene A. Gultian, Roshni Gandhi, Khushi Sarin, Martina Sladkova-Faure, Matthew Zimmer, Giuseppe Maria de Peppo & Sebastián L. Vega. Scientific Reports. 2022. DOI: https://doi.org/10.1038/s41598-022-12143-2

Modular deep learning enables automated identification of monoclonal cell lines
Brodie Fischbacher, Sarita Hedaya, Brigham J. Hartley, Zhongwei Wang, Gregory Lallos, Dillion Hutson, Matthew Zimmer, Jacob Brammer, The NYSCF Global Stem Cell Array Team, & Daniel Paull. Nature Machine Intelligence. (May, 2021). DOI: https://doi.org/10.1038/s42256-021-00354-7

Human Pluripotent Stem Cell Differentiation to Microglia
Laraib Ijaz, Madhura Nijsure, Valentina Fossati. Methods in Molecular Biology. (March, 2021). DOI: doi.org/10.1007/7651_2021_359

Cost and Time Effective Lithography of Reusable Millimeter Size Bone Tissue Replicas With Sub-15 nm Feature Size on A Biocompatible Polymer
Xiangyu Liu, Alessandra Zanut, Martina Sladkova-Faure, Liyuan Xie, Marcus Weck, Xiaorui Zheng, Elisa Riedo, Giuseppe Maria de Peppo. Advanced Functional Materials (February, 2021). DOI: https://doi.org/10.1002/adfm.202008662

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets
Ryan A. Neff, Minghui Wang, Sezen Vatansever, Lei Guo, Chen Ming, Qian Wang, Erming Wang, Emrin Horgusluoglu-Moloch, Won-Min Song, Aiqun Li, Emilie L. Castranio, Julia Tcw, Lap Ho, Alison Goate, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich, Pavel Katsel, Eric Schadt, Dongming Cai, Kristen J. Brennand, Vahram Haroutunian, Bin Zhang. Science Advances. 2021. DOI: https://doi.org/10.1126/sciadv.abb5398

2020

2019

GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in a human iPSC model of Alexander disease
Li Li, E Tian, Xianwei Chen, Jianfei Chao, Jeremy Klein, Qiuhao Qu, Guihua Sun, Guoqiang Sun, Yanzhou Huang, Charles D. Warden, Peng Ye, Lizhao Feng, Xinqiang Li, Qi Cui, Abdullah Sultan, Panagiotis Douvaras, Valentina Fossati, Neville E. Sanjana, Arthur D. Riggs, and Yanhong Shi. Cell Stem Cell. 2019. DOI: 10.1016/j.stem.2018.07.009

Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions
Jie Gong, Hui Cai, NYSCF Global Stem Cell Array Team, Scott Noggle, Daniel Paull, Lawrence J. Rizzolo, Lucian V. Del Priore, Mark A. Fields. Stem Cells Translational Medicine. 2019. DOI: 10.1002/sctm.19-0321.

Institutional Report Cards for Gender Equality: Lessons Learned from Benchmarking Efforts for Women in STEM
Whitney H. Beeler, Kristin A. Smith-Doody, Richard Ha, Raeka S. Aiyar, Elizabeth Schwarzbach, Susan L. Solomon, Reshma Jagsi. Cell Stem Cell, Vol. 25, Issue 3, p306–310. DOI: 10.1016/j.stem.2019.08.010.

Hypothermic and cryogenic preservation of tissue-engineered human bone
Tam E, McGrath M, Sladkova M, AlManaie A, Alostaad A, de Peppo GM. Annals of the New York Academy of Sciences. 2019. DOI: 10.1111/nyas.14264.

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells
Martín-Maestro P, Sproul A, Martinez H, Paquet D, Gerges M, Noggle S, Starkov AA. Molecular Neurobiology. 2019. DOI: 10.1111/nyas.14264

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis
Maureen Wentling, Carlos Lopez-Gomez, Hye-Jin Park, Mario Amatruda, Achilles Ntranos, James Aramini, Maria Petracca, Tom Rusielewicz, Emily Chen, Vladimir Tolstikov, Michael Kiebish, Valentina Fossati, Matilde Inglese Catarina, M Quinzii, Ilana Katz Sand, Patrizia Casaccia. Brain. 2019. DOI: 10.1093/brain/awz201

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L. 2019. Cell Stem Cell 25, 1-17 July 3, 2019. DOI: 10.1016/j.stem.2019.05.001

High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD
Cai H, Gong J, Abriola L, Hoyer D, Stem Cell Array Team NG, Noggle S, Paull D, Del Priore LV, Fields MA. Experimental Eye Research. 2019 Apr 10. DOI: 10.1016/j.exer.2019.04.009

CD49f is a novel marker to purify functional human iPSC-derived astrocytes
Lilianne Barbar, Tanya Jain, Matthew Zimmer, Ilya Kruglikov, Suzanne R. Burstein, Tomasz Rusielewicz, Madhura Nijsure, Gist Croft, Minghui Wang, Bin Zhang, Shane Liddelow, Valentina Fossati. BioRxiv. 2019. DOI:https://doi.org/10.1101/678359

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis 
Alexandra M. Nicaise, Laura J. Wagstaff, Cory M. Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, and Stephen J. Crocker. PNAS. March 25, 2019. DOI: 10.1073/pnas.1818348116

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells
McGrath M, Tam E, Sladkova M, AlManaie A, Zimmer M, de Peppo GM. 2019. Stem Cell Research and Therapy. DOI: 10.1016/j.msard.2018.11.032

2018

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development
Donna L. McPhie, Ralda Nehme, Caitlin Ravichandran, Suzann M. Babb, Sulagna Dia Ghosh, Alexandra Staskus, Amy Kalinowski, Rupinderjit Kaur, Panagiotis Douvaras, Fei Du, Dost Ongur, Valentina Fossati, Kevin Eggan & Bruce M. Cohen. 2018. Translational Psychiatry. DOI: https://doi.org/10.1038/s41398-018-0284-6

Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Masvekar R, Wu T, Kosa P, Barbour C, Fossati V, Bielekova B. Multiple Sclerosis and Related Disorders. 2018. DOI: 10.1016/j.msard.2018.11.032

Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells
Sladkova M, Cheng J, Palmer M, Chen S, Lin C, Xia W, Yu YE, Zhou B, Engqvist H, de Peppo GM. Tissue Engineering Part A. 2018. DOI: 10.1089/ten.TEA.2018.0149.

Induction of myelinating oligodendrocytes in human cortical spheroids
Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ. Nature Methods. 2018. DOI: 10.1038/s41592-018-0081-4.

Segmental Additive Tissue Engineering
Sladkova M, Alawadhi R, Alhaddad RJ, Esmael A, Alansari S, Saad M, Yousef JM, Alqaoud L, de Peppo GM. Scientific Reports. 2018. DOI: 10.1038/s41598-018-29270-4.

2017

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
Zachary S. Nevin, Daniel C. Factor, Robert T. Karl, Panagiotis Douvaras, Jeremy Laukka, Martha S. Windrem, Steven A. Goldman, Valentina Fossati, Grace M. Hobson, and Paul J. Tesar. Nevin, Z. S., Factor, D. C., Karl, R. T., Douvaras, P., Laukka, J., Windrem, M. S., Goldman, S. A., Fossati, V., Hobson, G. M., & Tesar, P. J. American Journal of Human Genetics. 2017. DOI: https://doi.org/10.1016/j.ajhg.2017.03.005

Derivation and characterization of the NYSCFe003-A human embryonic stem cell line
Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S. Stem Cell Research. 2017. DOI: 10.1016/j.scr.2017.10.017.

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons
Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. Acta Neuropathologica Communications. 2017. DOI: 10.1186/s40478-017-0475-z.

Contributions of bone morphogenetic proteins in cardiac repair cells in three‐dimensional in vitro models and angiogenesis
Pallotta I, Sun B, Lallos G, Terrenoire C, Freytes DO. Journal of Tissue Engineering and Regenerative Medicine. 2017. DOI: 10.1002/term.2460.

Directed Differentiation of Human Pluripotent Stem Cells to Microglia
Douvaras P, Sun B, Wang M, Kruglikov I, Lallos G, Zimmer M, Terrenoire C, Zhang B, Gandy S, Schadt E, Freytes DO, Noggle S, Fossati V. Stem Cell Reports. 2017. DOI: 10.1016/j.stemcr.2017.04.023.

2016

A viral strategy for targeting and manipulating interneurons across vertebrate species
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag A, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. Nature Neuroscience. 2016. DOI: 10.1038/nn.4430.

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes
Yamada M, Emmanuele V, Sanchez-Quintero MJ, Sun B, Lallos G, Paull D, Zimmer M, Pagett S, Prosser RW, Sauer MV, Hirano M, Egli D. Cell Stem Cell. 2016. DOI: 10.1016/j.stem.2016.04.001.

Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes
Douvaras P, Rusielewicz T, Kim KH, Haines JD, Casaccia P, Fossati V. International Journal of Molecular Sciences. 2016. DOI: 10.3390/ijms17040614.

Raising the standards of stem cell line quality
Yaffe MP, Noggle SA, Solomon SL. Nature Cell Biology. 2016. DOI: 10.1038/ncb3313.

2015

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization
Spiller KL, Wrona EA, Romero-Torres S, Pallotta I, Graney PL, Witherel CE, Panicker LM, Feldman RA, Urbanska AM, Santambrogio L, Vunjak-Novakovic G, Freytes DO. Experimental Cell Research. 2015. DOI: 10.1016/j.yexcr.2015.10.017.

From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer?
Yamada M, Byrne J, Egli D. Current Opinion in Genetics & Development. 2015. DOI: 10.1016/j.gde.2015.06.007.

Controlled release of cytokines using silk-biomaterials for macrophage polarization
Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. Biomaterials. 2015. DOI: 10.1016/j.biomaterials.2015.09.027.

Derivation and characterization of porcine vocal fold extracellular matrix scaffold
Wrona EA, Peng R, Born H, Amin MR, Branski RC, Freytes DO. Laryngoscope. 2015. DOI: 10.1002/lary.25640.

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz DN, Martinez H, Malicdan MCV, Weiss KA, Vensand LB, Dusenberry CR, Polus H, Sy KTL, Kahler DJ, Gahl WA, Solomon SL, Chang S, Meissner A, Eggan K, Noggle SA.
Nature Methods. 2015. DOI: 10.1038/nmeth.3507.

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells
Douvaras P, Fossati V. Nature Protocols. 2015. DOI: 10.1038/nprot.2015.075.

BMP protein‐mediated crosstalk between inflammatory cells and human pluripotent stem cell‐derived cardiomyocytes
Pallotta I, Sun B, Wrona EA, Freytes DO. Journal of Tissue Engineering and Regenerative Medicine. 2015. DOI: 10.1002/term.2045.

Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood
Zhou H, Martinez H, Sun B, Li A, Zimmer M, Katsanis N, Davis EE, Kurtzberg J, Lipnick S, Noggle S, Rao M, Chang S.
Stem Cell Reviews and Reports. 2015. DOI: 10.1007/s12015-015-9586-8.

Can cord blood banks transform into induced pluripotent stem cell banks?
Zhou H, Rao MS. Cytotherapy. 2015. DOI: 10.1016/j.jcyt.2015.02.008.

Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine
Smith KA, Arlotta P, Watt FM, The Initiative on Women in Science and Engineering Working Group, Solomon SL.
Cell Stem Cell. 2015. DOI: 10.1016/j.stem.2015.02.012.

Toward beta cell replacement for diabetes
Johannesson B, Sui L, Freytes DO, Creusot RJ, Egli D. EMBO Journal. 2015. DOI: 10.15252/embj.201490685.

Differentiation of hypothalamic-like neurons from human pluripotent stem cells
Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Carli JM, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. The Journal of Clinical Investigation. 2015. DOI: 10.1172/JCI79220.

Banking on iPSC–is it doable and is it worthwhile
Solomon S, Pitossi F, Rao MS. Stem Cell Reviews and Reports. 2015. DOI: 10.1007/s12015-014-9574-4.

2014

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, Brock M, Lipnick S, Rao M, Chang S, Li A, Noggle SA. Cell Reports. 2014. DOI: 10.1016/j.celrep.2014.10.023.

Comparable Frequencies of Coding Mutations and Loss of Imprinting in Human Pluripotent Cells Derived by Nuclear Transfer and Defined Factors
Johannesson B, Sagi I, Gore A, Paull D, Yamada M, Golan-Lev T, Li Z, LeDuc C, Shen Y, Stern S, Xu N, Ma H, Kang E, Mitalipov S. Cell Stem Cell. 2014. DOI: 10.1016/j.stem.2014.10.002.

Macrophages modulate engineered human tissues for enhanced vascularization and healing
Spiller KL1, Freytes DO, Vunjak-Novakovic G. Annals of Biomedical Engineering. 2014. DOI: 10.1007/s10439-014-1156-8.

Genetic validation of a therapeutic target in a mouse model of ALS
de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Science Translational Medicine. 2014. DOI: 10.1126/scitranslmed.3009351.

A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs)
Prè D, Nestor MW, Sproul AA, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O.
PloS One. 2014. DOI: 10.1371/journal.pone.0103418.

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells
Douvaras P, Wang J, Zimmer M, Hanchuk S, O’Bara MA, Sadiq S, Sim FJ, Goldman J, Fossati V. Stem Cell Reports. 2014. DOI: 10.1016/j.stemcr.2014.06.012.

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects
Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH. Molecular Therapy. 2014. DOI: 10.1038/mt.2014.100.

Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
de Peppo GM, Agheli H, Karlsson C, Ekström K, Brisby H, Lennerås M, Gustafsson S, Sjövall P, Johansson A, Olsson E, Lausmaa J, Thomsen P, Petronis S. International Journal of Nanomedicine. 2014. DOI: 10.2147/IJN.S58805.

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells
Yamada M, Johannesson B, Sagi I, Burnett LC, Kort DH, Prosser RW, Paull D, Nestor MW, Freeby M, Greenberg E, Goland RS, Leibel RL, Solomon SL, Benvenisty N, Sauer MV, Egli D. Nature. 2014. DOI: 10.1038/nature13287.

Bioreactor Systems for Human Bone Tissue Engineering
Sladkova M, de Peppo GM. Processes. 2014. DOI: 10.3390/pr2020494.

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors
Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA. PLoS One. 2014. DOI: 10.1371/journal.pone.0084547.

Generation of iPSC lines from archived non-cryoprotected biobanked dura mater
Sproul AA, Vensand LB, Dusenberry CR, Jacob S, Vonsattel JPG, Paull DJ, Shelanski ML, Crary JF, Noggle SA. Acta Neuropathologica Communications. 2014. DOI: 10.1186/2051-5960-2-4.

2013

Bioreactor engineering of stem cell environments

Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G. Biotechnology Advances. 2013. DOI: 10.1016/j.biotechadv.2013.03.007.

Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome
Shang L, Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler DJ, Freeby M, Chung W, LeDuc C, Goland R, Leibel RL, Egli D. Diabetes. 2013. DOI: 10.2337/db13-0717.

Make no bones about it: cells could soon be reprogrammed to grow replacement bones?
de Peppo GM, Marolt D. Expert Opinion on Biological Therapy. 2013. DOI: 10.1517/14712598.2013.840581.

Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors
de Peppo GM, Marolt D. Stem Cell Research & Therapy. 2013. DOI: 10.1186/scrt317

Engineering bone tissue substitutes from human induced pluripotent stem cells
de Peppo GM, Marcos-Campos I, Kahler DJ, Alsalman D, Shang L, Vunjak-Novakovic G, Marolt D. Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI: 10.1073/pnas.1301190110.

Human progenitor cells for bone engineering applications
de Peppo GM, Thomsen P, Karlsson C, Strehl R, Lindahl A, Hyllner J. Current Molecular Medicine. 2013. DOI: 10.2174/1566524011313050004.

Standardization of human stem cell pluripotency using bioinformatics
Nestor MW, Noggle SA. Stem Cell Research and Therapy. 2013. DOI: 10.1186/scrt185.

Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting
Kahler DJ, Ahmad FS, Ritz A, Hua H, Moroziewicz DN, Sproul AA, Dusenberry CR, Shang L, Paull D, Zimmer M, Weiss KA, Egli D, Noggle SA. PLoS One. 2013. DOI: 10.1371/journal.pone.0059867.

Differentiation of serum-free embryoid bodies from human induced pluripotent stem cells into networks
Nestor MW, Paull D, Jacob S, Sproul AA, Alsaffar A, Campos BA, Noggle SA. Stem Cell Research. 2013. DOI: 10.1016/j.scr.2013.02.001.

SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism
Ozair MZ1, Noggle S, Warmflash A, Krzyspiak JE, Brivanlou AH. Stem Cells. 2013. DOI: 10.1002/stem.1246.

2012

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
Paull D, Emmanuele V, Weiss KA, Treff N, Stewart L, Hua H, Zimmer M, Kahler DJ, Goland RS, Noggle SA, Prosser R, Hirano M, Sauer MV, Egli D. Nature. 2012. DOI: 10.1038/nature11800.

Human oocytes reprogram somatic cells to a pluripotent state
Noggle S, Fung H, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D. Nature. 2012. DOI: 10.1038/nature10397.

Developmental potential of late maturing human oocytes after parthenogenetic artificial activation
Lee J, Barritt J, Paull D, Martinez H, Egli D, Copperman AB. Fertility and Sterility. 2012. DOI: 10.1016/j.fertnstert.2012.07.077.

Human embryonic stem cell-derived mesodermal progenitors display substantially increased tissue formation compared to human mesenchymal stem cells under dynamic culture conditions in a packed bed/column bioreactor
de Peppo GM, Sladkova M, Sjövall P, Palmquist A, Oudina K, Hyllner J, Thomsen P, Petite H, Karlsson C.
Tissue Engineering Part A. 2012. DOI: 10.1089/ten.TEA.2011.0412.

Mouse ooplasm confers context-specific reprogramming capacity
Chan MM, Smith ZD, Egli D, Regev A, Meissner A. Nature Genetics. 2012. DOI: 10.1038/ng.2382. 

Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa
Li Y, Tsai YT, Hsu CW, Erol D, Yang J, Wu WH, Davis RJ, Egli D, Tsang SH. Molecular Medicine. 2012. DOI: 10.2119/molmed.2012.00242.

Human cord blood applications in cell therapy: looking back and look ahead
Zhou H, Chang S, Rao M. Expert Opinions in Biological Therapy. 2012. DOI: 10.1517/14712598.2012.691161.

The sixth annual translational stem cell research conference of the New York Stem Cell Foundation
Marshall C, Hua H, Shang L, Ding BS, Zito G, de Peppo GM, Wang GK, Douvaras P, Sproul AA, Paull D, Fossati V, Nestor MW, McKeon D, Smith KA, Solomon SL. Annals of the New York Academy of Sciences. 2012. DOI: 10.1111/j.1749-6632.2012.06481.x

Engineering bone tissue from human embryonic stem cells
Marolt D, Marcos Campos I, Bhumiratana S, Koren A, Petridis P, Zhang G, Spitalnik PF, Grayson WL, and Vunjak-Novakovic G. Proceedings of the National Academy of Sciences of the United States of America. 2012. DOI: 10.1073/pnas.1201830109.

The New York Stem Cell Foundation: Accelerating Cures Through Stem Cell Research
Susan L. Solomon. Stem Cells Translational Medicine. 2012. DOI: 10.5966/sctm.2012-0019.

2011

2010