About Alzheimer's Alzheimer's Research at NYSCF Alzheimer's News Publications
About Alzheimer’s Disease
Alzheimer’s disease is a devastating neurological disease that causes dementia and eventually leads to death. Though symptoms manifest differently in each patient, many early-stage patients become forgetful and confused. As the disease advances, patients can experience long-term memory loss, mood swings, difficulty in speech, and personality changes. 5.4 million people in the United States are living with this disease and 8.2 million more will be diagnosed by 2050.
The two hallmarks of Alzheimer’s pathology are amyloid-beta plaques and neuron tangles—structural abnormalities found in the brain. However, we do not know the exact mechanisms by which these abnormalities lead to the disease, or how big of a role each plays in its onset.
Alzheimer’s Disease Research at NYSCF
At NYSCF, we are studying the actual human cells affected by Alzheimer’s and developing treatment strategies. We are doing this in several ways:
- At the NYSCF Research Institute, we are using our own, powerful robotic system for creating stem cells. Our NYSCF Global Stem Cell Array can rapidly, cleanly, and reproducibly create stem cells from skin or blood, and then reprogram them to become the neurons implicated in Alzheimer’s.
- Once made, these neurons allow us to investigate the molecular and cellular causes of Alzheimer’s as it develops so that we may see the actual decline and failure of diseased cells.
- We can also use these cells to rapidly and efficiently test drug efficacy and potential toxicity, identifying the safest and most promising compounds to advance to clinical trials.