Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells
Martín-Maestro P, Sproul A, Martinez H, Paquet D, Gerges M, Noggle S, Starkov AA. Molecular Neurobiology. 2019. doi: 10.1007/s12035-019-01665-y.

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis
Maureen Wentling, Carlos Lopez-Gomez, Hye-Jin Park, Mario Amatruda, Achilles Ntranos, James Aramini, Maria Petracca, Tom Rusielewicz, Emily Chen, Vladimir Tolstikov, Michael Kiebish, Valentina Fossati, Matilde Inglese Catarina, M Quinzii, Ilana Katz Sand, Patrizia Casaccia. Brain. 2019. doi:

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L. 2019. Cell Stem Cell 25, 1-17 July 3, 2019.

High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD
Cai H, Gong J, Abriola L, Hoyer D, Stem Cell Array Team NG, Noggle S, Paull D, Del Priore LV, Fields MA. Experimental Eye Research. 2019 Apr 10. doi: 10.1016/j.exer.2019.04.009.

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis 
Alexandra M. NicaiseLaura J. WagstaffCory M. WillisCarolyn PaisieHarshpreet ChandokPaul RobsonValentina FossatiAnna Williams, and Stephen J. Crocker. PNAS. March 25, 2019. DOI:

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells
McGrath M, Tam E, Sladkova M, AlManaie A, Zimmer M, de Peppo GM. 2019. Stem Cell Research and Therapy. DOI: 10.1186/s13287-018-1119-3.

Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Masvekar, Ruturaj et al. Multiple Sclerosis and Related Disorders. 2018. DOI:

Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells
Sladkova M, Cheng J, Palmer M, Chen S, Lin C, Xia W, Yu YE, Zhou B, Engqvist H, de Peppo GM. Tissue Engineering Part A. 2018. DOI: 10.1089/ten.tea.2018.0149.

Induction of myelinating oligodendrocytes in human cortical spheroids
Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ. Nature Methods. 2018. DOI: 10.1038/s41592-018-0081-4.

Segmental Additive Tissue Engineering
Sladkova M, Alawadhi R, Alhaddad RJ, Esmael A, Alansari S, Saad M, Yousef JM, Alqaoud L, de Peppo GM. Scientific Reports. 2018. DOI: 10.1038/s41598-018-29270-4.

Derivation and characterization of the NYSCFe003-A human embryonic stem cell line
Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S. Stem Cell Research. 2017. DOI: 10.1016/j.scr.2017.10.017.

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons
Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. Acta Neuropathologica Communications. 2017. DOI: 10.1186/s40478-017-0475-z.

Contributions of bone morphogenetic proteins in cardiac repair cells in three‐dimensional in vitro models and angiogenesis
Pallotta I, Sun B, Lallos G, Terrenoire C, Freytes DO. Journal of Tissue Engineering and Regenerative Medicine. 2017. DOI: 10.1002/term.2460.

Directed Differentiation of Human Pluripotent Stem Cells to Microglia
Douvaras P, Sun B, Wang M, Kruglikov I, Lallos G, Zimmer M, Terrenoire C, Zhang B, Gandy S, Schadt E, Freytes DO, Noggle S, Fossati V. Stem Cell Reports. 2017. DOI: 10.1016/j.stemcr.2017.04.023.

A viral strategy for targeting and manipulating interneurons across vertebrate species
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag A, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. Nature Neuroscience. 2016. DOI: 10.1038/nn.4430.

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes
Yamada M, Emmanuele V, Sanchez-Quintero MJ, Sun B, Lallos G, Paull D, Zimmer M, Pagett S, Prosser RW, Sauer MV, Hirano M, Egli D. Cell Stem Cell. 2016. DOI: 10.1016/j.stem.2016.04.001.

Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes
Douvaras P, Rusielewicz T, Kim KH, Haines JD, Casaccia P, Fossati V. International Journal of Molecular Sciences. 2016. DOI: 10.3390/ijms17040614.

Raising the standards of stem cell line quality
Yaffe MP, Noggle SA, Solomon SL. Nature Cell Biology. 2016. DOI: 10.1038/ncb3313.

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization
Spiller KL, Wrona EA, Romero-Torres S, Pallotta I, Graney PL, Witherel CE, Panicker LM, Feldman RA, Urbanska AM, Santambrogio L, Vunjak-Novakovic G, Freytes DO. Experimental Cell Research. 2015. DOI: 10.1016/j.yexcr.2015.10.017.

From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer?
Yamada M, Byrne J, Egli D. Current Opinion in Genetics & Development. 2015. DOI: 10.1016/j.gde.2015.06.007.

Controlled release of cytokines using silk-biomaterials for macrophage polarization
Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. Biomaterials. 2015. DOI: 10.1016/j.biomaterials.2015.09.027.

Derivation and characterization of porcine vocal fold extracellular matrix scaffold
Wrona EA, Peng R, Born H, Amin MR, Branski RC, Freytes DO. Laryngoscope. 2015. DOI: 10.1002/lary.25640.

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz DN, Martinez H, Malicdan MCV, Weiss KA, Vensand LB, Dusenberry CR, Polus H, Sy KTL, Kahler DJ, Gahl WA, Solomon SL, Chang S, Meissner A, Eggan K, Noggle SA.
Nature Methods. 2015. DOI: 10.1038/nmeth.3507.

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells
Douvaras P, Fossati V. Nature Protocols. 2015. DOI: 10.1038/nprot.2015.075.

BMP protein‐mediated crosstalk between inflammatory cells and human pluripotent stem cell‐derived cardiomyocytes
Pallotta I, Sun B, Wrona EA, Freytes DO. Journal of Tissue Engineering and Regenerative Medicine. 2015. DOI: 10.1002/term.2045.

Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood
Zhou H, Martinez H, Sun B, Li A, Zimmer M, Katsanis N, Davis EE, Kurtzberg J, Lipnick S, Noggle S, Rao M, Chang S.
Stem Cell Reviews and Reports. 2015. DOI: 10.1007/s12015-015-9586-8.

Can cord blood banks transform into induced pluripotent stem cell banks?
Zhou H, Rao MS. Cytotherapy. 2015. DOI: 10.1016/j.jcyt.2015.02.008.

Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine
Smith KA, Arlotta P, Watt FM, The Initiative on Women in Science and Engineering Working Group, Solomon SL.
Cell Stem Cell. 2015. DOI: 10.1016/j.stem.2015.02.012.

Toward beta cell replacement for diabetes
Johannesson B, Sui L, Freytes DO, Creusot RJ, Egli D. EMBO Journal. 2015. DOI: 10.15252/embj.201490685.

Differentiation of hypothalamic-like neurons from human pluripotent stem cells
Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Carli JM, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. The Journal of Clinical Investigation. 2015. DOI: 10.1172/JCI79220.

Banking on iPSC–is it doable and is it worthwhile
Solomon S, Pitossi F, Rao MS. Stem Cell Reviews and Reports. 2015. DOI: 10.1007/s12015-014-9574-4.

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, Brock M, Lipnick S, Rao M, Chang S, Li A, Noggle SA. Cell Reports. 2014. DOI: 10.1016/j.celrep.2014.10.023.

Comparable Frequencies of Coding Mutations and Loss of Imprinting in Human Pluripotent Cells Derived by Nuclear Transfer and Defined Factors
Johannesson B, Sagi I, Gore A, Paull D, Yamada M, Golan-Lev T, Li Z, LeDuc C, Shen Y, Stern S, Xu N, Ma H, Kang E, Mitalipov S. Cell Stem Cell. 2014. DOI: 10.1016/j.stem.2014.10.002.

Macrophages modulate engineered human tissues for enhanced vascularization and healing
Spiller KL1, Freytes DO, Vunjak-Novakovic G. Annals of Biomedical Engineering. 2014. DOI: 10.1007/s10439-014-1156-8.

Genetic validation of a therapeutic target in a mouse model of ALS
de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Science Translational Medicine. 2014. DOI: 10.1126/scitranslmed.3009351.

A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs)
Prè D, Nestor MW, Sproul AA, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O.
PloS One. 2014. DOI: 10.1371/journal.pone.0103418.

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells
Douvaras P, Wang J, Zimmer M, Hanchuk S, O’Bara MA, Sadiq S, Sim FJ, Goldman J, Fossati V. Stem Cell Reports. 2014. DOI: 10.1016/j.stemcr.2014.06.012.

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects
Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH. Molecular Therapy. 2014. DOI: 10.1038/mt.2014.100.

Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
de Peppo GM, Agheli H, Karlsson C, Ekström K, Brisby H, Lennerås M, Gustafsson S, Sjövall P, Johansson A, Olsson E, Lausmaa J, Thomsen P, Petronis S. International Journal of Nanomedicine. 2014. DOI: 10.2147/IJN.S58805.

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells
Yamada M, Johannesson B, Sagi I, Burnett LC, Kort DH, Prosser RW, Paull D, Nestor MW, Freeby M, Greenberg E, Goland RS, Leibel RL, Solomon SL, Benvenisty N, Sauer MV, Egli D. Nature. 2014. DOI: 10.1038/nature13287.

Bioreactor Systems for Human Bone Tissue Engineering
Sladkova M, de Peppo GM. Processes. 2014. DOI: 10.3390/pr2020494.

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors
Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA. PLoS One. 2014. DOI: 10.1371/journal.pone.0084547.

Generation of iPSC lines from archived non-cryoprotected biobanked dura mater
Sproul AA, Vensand LB, Dusenberry CR, Jacob S, Vonsattel JPG, Paull DJ, Shelanski ML, Crary JF, Noggle SA. Acta Neuropathologica Communications. 2014. DOI: 10.1186/2051-5960-2-4.

Bioreactor engineering of stem cell environments
Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G. Biotechnology Advances. 2013. DOI: 10.1016/j.biotechadv.2013.03.007.

Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome
Shang L, Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler DJ, Freeby M, Chung W, LeDuc C, Goland R, Leibel RL, Egli D. Diabetes. 2013. DOI: 10.2337/db13-0717.

Make no bones about it: cells could soon be reprogrammed to grow replacement bones?
de Peppo GM, Marolt D. Expert Opinion on Biological Therapy. 2013. DOI: 10.1517/14712598.2013.840581.

Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors
de Peppo GM, Marolt D. Stem Cell Research & Therapy. 2013. DOI: 10.1186/scrt317

Engineering bone tissue substitutes from human induced pluripotent stem cells
de Peppo GM, Marcos-Campos I, Kahler DJ, Alsalman D, Shang L, Vunjak-Novakovic G, Marolt D. Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI: 10.1073/pnas.1301190110.

Human progenitor cells for bone engineering applications
de Peppo GM1, Thomsen P, Karlsson C, Strehl R, Lindahl A, Hyllner J. Current Molecular Medicine. 2013. DOI: 10.2174/1566524011313050004.

Standardization of human stem cell pluripotency using bioinformatics
Nestor MW, Noggle SA. Stem Cell Research and Therapy. 2013. DOI: 10.1186/scrt185.

Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting
Kahler DJ, Ahmad FS, Ritz A, Hua H, Moroziewicz DN, Sproul AA, Dusenberry CR, Shang L, Paull D, Zimmer M, Weiss KA, Egli D, Noggle SA. PLoS One. 2013. DOI: 10.1371/journal.pone.0059867.

Differentiation of serum-free embryoid bodies from human induced pluripotent stem cells into networks
Nestor MW, Paull D, Jacob S, Sproul AA, Alsaffar A, Campos BA, Noggle SA. Stem Cell Research. 2013. DOI: 10.1016/j.scr.2013.02.001.

SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism
Ozair MZ1, Noggle S, Warmflash A, Krzyspiak JE, Brivanlou AH. Stem Cells. 2013. DOI: 10.1002/stem.1246.

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
Paull D, Emmanuele V, Weiss KA, Treff N, Stewart L, Hua H, Zimmer M, Kahler DJ, Goland RS, Noggle SA, Prosser R, Hirano M, Sauer MV, Egli D. Nature. 2012. DOI: 10.1038/nature11800.

Human oocytes reprogram somatic cells to a pluripotent state
Noggle S, Fung H, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D. Nature. 2012. DOI: 10.1038/nature10397.

Developmental potential of late maturing human oocytes after parthenogenetic artificial activation
Lee J, Barritt J, Paull D, Martinez H, Egli D, Copperman AB. Fertility and Sterility. 2012. DOI: 10.1016/j.fertnstert.2012.07.077.

Human embryonic stem cell-derived mesodermal progenitors display substantially increased tissue formation compared to human mesenchymal stem cells under dynamic culture conditions in a packed bed/column bioreactor
de Peppo GM, Sladkova M, Sjövall P, Palmquist A, Oudina K, Hyllner J, Thomsen P, Petite H, Karlsson C.
Tissue Engineering Part A. 2012. DOI: 10.1089/ten.TEA.2011.0412.

Mouse ooplasm confers context-specific reprogramming capacity
Chan MM, Smith ZD, Egli D, Regev A, Meissner A. Nature Genetics. 2012. DOI: 10.1038/ng.2382.

Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa
Li Y, Tsai YT, Hsu CW, Erol D, Yang J, Wu WH, Davis RJ, Egli D, Tsang SH. Molecular Medicine. 2012. DOI: 10.2119/molmed.2012.00242.

Human cord blood applications in cell therapy: looking back and look ahead
Zhou H, Chang S, Rao M. Expert Opinions in Biological Therapy. 2012. DOI:10.1517/14712598.2012.691161.

The sixth annual translational stem cell research conference of the New York Stem Cell Foundation
Marshall C, Hua H, Shang L, Ding BS, Zito G, de Peppo GM, Wang GK, Douvaras P, Sproul AA, Paull D, Fossati V, Nestor MW, McKeon D, Smith KA, Solomon SL. Annals of the New York Academy of Sciences. 2012. DOI: 10.1111/j.1749-6632.2012.06481.x

Engineering bone tissue from human embryonic stem cells
Marolt D, Marcos Campos I, Bhumiratana S, Koren A, Petridis P, Zhang G, Spitalnik PF, Grayson WL, and Vunjak-Novakovic G. Proceedings of the National Academy of Sciences of the United States of America. 2012. DOI: 10.1073/pnas.1201830109.

The New York Stem Cell Foundation: Accelerating Cures Through Stem Cell Research
Susan L. Solomon. Stem Cells Translational Medicine. 2012. DOI: 10.5966/sctm.2012-0019.

Human oocytes reprogram somatic cells to a pluripotent state
Noggle S, Fung HL, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D. Nature. 2011. DOI: 10.1038/nature10397.

Impracticality of egg donor recruitment in the absence of compensation
Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Cell Stem Cell. 2011. DOI: 10.1016/j.stem.2011.08.002.

Reprogramming within hours following nuclear transfer into mouse but not human zygotes
Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Nature Communications. 2011. DOI: 10.1038/ncomms1503.

The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference
Marshall C, Wang GK, Cimetta E, Talchai C, Egli D, Shim JW, Martin I, Ahmad F, Sproul A, Chen T, Fossati V, McKeon D, Smith K, Solomon SL. Annals of the New York Academy of Sciences. 2011. DOI: 10.1111/j.1749-6632.2011.06038.x

A functionally characterized test set of human induced pluripotent stem cells
Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. Nature Biotechnology. 2011. DOI: 10.1038/nbt.1783.

Breaking ground on translational stem cell research
Hall ZW, Kahler D, Manganiello M, Egli D, James D, Marolt D, Fasano C, Ichida J, Noggle S, Solomon SL, McKeon D, Smith K, Marshall C. Annals of the New York Academy of Sciences. 2010. DOI: 10.1111/j.1749-6632.2010.05495.x