NYSCF Global Stem Cell Array®

Automated iPSC reprogramming, genome editing, and differentiation

Developed by NYSCF scientists and engineers, the NYSCF Global Stem Cell Array®, our fully robotic platform that brings the power of automation to stem cell research and disease modeling, allows scientists to study how disease affects patient populations.

Best-in-class Cell Culture Automation Technology

  • Eliminates all manual manipulation, addressing technical noise
  • Significantly reduces line-to-line variability, addressing biological noise
  • Yields highly reproducible panels of iPSCs and differentiated lines
  • Massively parallel processing of samples

Read our Nature Methods paper

Capabilities and Resources

1. Access to NYSCF repository of thousands of iPSC lines from genetically diverse patients, healthy populations spanning ~300 diseases

2. Fully automated reprogramming of skin and blood samples into iPSCs

  • Population-scale, high-throughput cell culture methods
  • Traceable processes and project management infrastructure
  • Certificate of Analysis provided for each line verifying rigorous quality control

3. Automated genome editing for functional genomics studies

  • Automated CRISPR/Cas9 knockouts
  • SNV edits for production of isogenic line pairs

4. High-yield protocols for differentiating PSCs into various cell types, including neuronal, glial, pancreatic, cardiac, hepatic, retinal pigmented epithelial, cardiomyocytes, immune

  • Numerous protocols automated and scaled up
  • Marker-based isolation of pure differentiated populations
  • Multiple protocols for pancreatic and cortical organoid generation; some already automated

5. Ability to scale up phenotypic and functional characterizations of interest in 2D or 3D cultures

6. PI-led research teams with active disease programs (diabetes, Parkinson’s, Alzheimer’s, multiple sclerosis, age-related macular degeneration, cancer) and high-impact publications

For more details about the NYSCF Global Stem Cell Array®, download our brochure here.

If you are interested in collaborative opportunities using the NYSCF Global Stem Cell Array®, please contact partnering@nyscf.org.