NYSCF Scientists Develop iPS Cell Model of Alzheimer’s Disease, A Key Step to Understanding Disease
At the Alzheimer’s Association International Conference this past July, Andrew Sproul, PhD, a NYSCF Postdoctoral Associate, presented NYSCF’s latest efforts to understand Alzheimer’s disease. They have generated relevant induced pluripotent stem (iPS) cell models from AD patients and well relatives that were then differentiated into cholinergic neurons. Other efforts in the generation of human iPS cell disease models include cortical neurons from Down’s syndrome patients and the creation of cell lines from ALS patients. These iPS lines reveal the underlying biology that animal models do not.