Progress in Pluripotency
“It has been less than three years since Takahashi and Yamanaka demonstrated that viral transduction of the four-factor cocktail...“It has been less than three years since Takahashi and Yamanaka demonstrated that viral transduction of the four-factor cocktail of Oct4, KLF4, Sox2, and c-Myc transgenes was sufficient to convert fibroblasts into ESC-like cells.”