Ravi Majeti Uncovers Mutation Acquisition of Blood-Forming Stem Cells in Leukemia

Tackling the question of why some cells become cancerous, Ravi Majeti, MD, PhD, a NYSCF – Robertson Investigator, and researchers at Stanford University made a landmark discovery, with results published in Science and Translational Medicine. Their group hypothesized that hematopoietic stem cells (or blood-forming cells) acquire mutations that lead to blood cancers. By genetically sequencing blood-forming cells from leukemia patients, they identified a series of mutations and even the order in which they arose. This may explain why some leukemia patients relapse after treatment and point the way to more effective treatments.

Read more about this study on Science and Translational Medicine >>