NYSCF in the News & Research Spotlight

Utilizing Expansion Microscopy for Diagnosis
Utilizing Expansion Microscopy for Diagnosis

NYSCF - Robertson Neuroscience Investigator Alumnus Dr. Ed Boyden, a professor at MIT Media Lab, has developed a new technique for precisely imaging biopsy samples utilizing standard microscopes. The technique, dubbed “expansion pathology,” relies on a revolutionary imaging approach developed by Dr. Boyden and his team known as expansion microscopy. 

 

In expansion pathology, researchers dissolve the fixing agents used in biopsy samples, such as paraffin, and chemically tag landmarks within the sample. Then, using an expanding polymer gel, they physically swell a tissue sample to 100 times its original volume before imaging it. This approach offers detailed information about disease pathology and more informative biopsies while simultaneously negating the need for expensive specialized imaging equipment like electron microscopes. 

 

Reported in Nature Biotechnology, this technique can be applied to a range of diseases including cancer and kidney diseases.

 

 

Read the press release in MIT News >>

 

Watch a video from MIT News >>

 

Read hte paper in Nature Biotechnology >>

Modeling the Digestive Tract using Stem Cells
Modeling the Digestive Tract using Stem Cells

NYSCF – Robertson Stem Cell Investigator Alumna Dr. Shuibing Chen at Weill Cornell Medical School successfully developed a protocol for deriving organoids representing the human digestive tract from stem cells. The scientists derived these 'colonic organoids' from both embryonic stem cells and from induced pluripotent stem cells derived from a patient with a genetic digestive tract disease. Utilizing the iPS cells, Dr. Chen and her team further identified a potential treatment for the condition. 

Published in Nature Medicine, the protocol for creating the colonic organoids can be used in disease modeling and drug discovery for colorectal disease, including cancer and genetic afflictions.

 

Read the paper in Nature Medicine >>

Engineering Livers from Stem Cells
Engineering Livers from Stem Cells
NYSCF – Robertson Stem Cell Investigator Dr. Takanori Takebe of Cincinnati Children’s Hospital Medical Center led an international team of researchers in bioengineering human liver tissues. The research, published in Nature, uncovered previously unknown networks of genetic-molecular crosstalk that control the developmental processes leading to liver tissue, greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.
 
This research could lead to both better drug development and testing for liver disorders, as well as to future cell and even whole organ replacement therapies using tissues derived from stem cells.
 
 
 
 
Noninvasive Deep Brain Stimulation
Noninvasive Deep Brain Stimulation
Deep brain stimulation via implanted electrodes has proven an effective therapy for Parkinson’s disease, epilepsy, and depression among other disorders; however, it remains an invasive and risky operation. NYSCF - Robertson Neuroscience Investigator Dr. Ed Boyden and his team at MIT Media Lab have developed a revolutionary new method of noninvasive deep brain stimulation. 
 
Published in Cell, the scientists, in collaboration with researchers from Beth Israel Deaconess Medical Center and the IT’IS Foundation created a way to send electrical signals deep within the brain via electrodes placed on the scalp, as opposed to implanting them deep within the brain at the area of interest. The scientists accomplished this feat via a phenomenon called temporal interference, where two electrodes create a treatment area only where their radiating electrical currents intersect. 
 
This breakthrough has broad implications for patients and scientists, enabling easier and safer delivery of deep brain stimulation for treatment and opening up new avenues of research that were previously prohibitively expensive and risky. 

 

Read the press release from MIT News >>

Read the paper in Cell >>

NYSCF Innovator Discovers Brain Network for Interpreting Social Interactions
NYSCF Innovator Discovers Brain Network for Interpreting Social Interactions

How primates, including humans, easily and effortlessly process social interactions such as playing, fighting and grooming has historically been shrouded in mystery. NYSCF – Robertson Neuroscience Investigator Dr. Winrich Freiwald published his latest work in Science describing an exclusive brain region for social cognition. By studying the brain functions of monkeys as they watched videos using functional magnetic resonance imaging (fMRI), Dr. Freiwald and his colleague at The Rockefeller University discovered that there is a dedicated network of neurons for social interaction processing in the primate brain. These findings may translate to aspects of human cognition and brain functioning. 

 

Read the press release on EurekAlert >>

Read the paper in Science >>

  • NYSCF Press Releases

    A Robust, High-Throughput Protocol for Deriving Microglia From Human Stem Cells
    NYSCF Research Institute scientists have developed a robust, efficient method for deriving microglia, the immune cells of the brain, from human stem cells. Microglia are…

    Read more »
    NYSCF Opens New Research Institute and Headquarters in Manhattan
    NYSCF officially opened its new state-of-the-art Research Institute and headquarters in Manhattan. The expanded NYSCF Research Institute will allow scientists to conduct the most advanced…

    Read more »
    Partnership Results in the Availability of Fully-Sequenced Stem Cell Lines
    A collaboration beginning in 2013 between the NYSCF Research Institute and the Personal Genome Project (PGP) resulted in the availability of a unique new stem…

    Read more »
    Feng Zhang Receives 2016 NYSCF – Robertson Stem Cell Prize
    NYSCF announced today that Feng Zhang, PhD, is the 2016 recipient of the NYSCF – Robertson Stem Cell Prize for his pioneering advances to edit…

    Read more »
    NYSCF Announces the Six Members of the 2016 Class of NYSCF - Robertson Investigators
    NYSCF announced the 2016 class of NYSCF – Robertson Investigators, welcoming six of the most talented stem cell researchers and neuroscientists from around the world…

    Read more »
  • News
    You are here: News