NYSCF – Robertson Investigator Analyzes Utility of Gene Sequencing Method
NYSCF – Robertson Stem Cell Investigator Dr. Alex Meissner, of Harvard University, published his recent analysis of whole-genome buslfate sequencing (WGBS). This sequencing method allows scientists to analyze an entire genome for DNA methylation patterns, but it remains underutilized due to high costs.
Dr. Meissner and his team used reference data to analyze miminum sequencing requirements, as compared to whole genome sequencing. The scientists identified trade-offs with increasing or decreasing sequencing coverage in their report, published in Nature Methods.