Scientists Turn Mature Blood Cells Into Blood-Forming Stem Cells

NYSCF – Robertson Stem Cell Investigator Dr. Derrick Rossi and a team of scientists at the Harvard Stem Cell Institute have reprogrammed mature mouse blood cells into blood-forming stem cells. Published in Cell, the scientists used a combination of eight genetic switches, or transcription factors, to reprogram the cells into becoming hematopoietic, or blood-forming, stem cells. The cells created are able to self renew and give rise to all the components of blood in the same way as native blood-forming stem cells. 

One of the most sought-after goals of regenerative medicine is to create functional hematopoietic stem cells for transplantation therefore eliminating the need for bone marrow transplants. 


Read more about this breakthrough in the Harvard Gazette >>

Read the paper in Cell >>