NYSCF in the News & Research Spotlight

Noninvasive Deep Brain Stimulation
Noninvasive Deep Brain Stimulation
Deep brain stimulation via implanted electrodes has proven an effective therapy for Parkinson’s disease, epilepsy, and depression among other disorders; however, it remains an invasive and risky operation. NYSCF - Robertson Neuroscience Investigator Dr. Ed Boyden and his team at MIT Media Lab have developed a revolutionary new method of noninvasive deep brain stimulation. 
 
Published in Cell, the scientists, in collaboration with researchers from Beth Israel Deaconess Medical Center and the IT’IS Foundation created a way to send electrical signals deep within the brain via electrodes placed on the scalp, as opposed to implanting them deep within the brain at the area of interest. The scientists accomplished this feat via a phenomenon called temporal interference, where two electrodes create a treatment area only where their radiating electrical currents intersect. 
 
This breakthrough has broad implications for patients and scientists, enabling easier and safer delivery of deep brain stimulation for treatment and opening up new avenues of research that were previously prohibitively expensive and risky. 

 

Read the press release from MIT News >>

Read the paper in Cell >>

NYSCF Innovator Discovers Brain Network for Interpreting Social Interactions
NYSCF Innovator Discovers Brain Network for Interpreting Social Interactions

How primates, including humans, easily and effortlessly process social interactions such as playing, fighting and grooming has historically been shrouded in mystery. NYSCF – Robertson Neuroscience Investigator Dr. Winrich Freiwald published his latest work in Science describing an exclusive brain region for social cognition. By studying the brain functions of monkeys as they watched videos using functional magnetic resonance imaging (fMRI), Dr. Freiwald and his colleague at The Rockefeller University discovered that there is a dedicated network of neurons for social interaction processing in the primate brain. These findings may translate to aspects of human cognition and brain functioning. 

 

Read the press release on EurekAlert >>

Read the paper in Science >>

Sharing NYSCF's Voice on Big Data, Precision Medicine and Innovative Business Models
Sharing NYSCF's Voice on Big Data, Precision Medicine and Innovative Business Models
NYSCF CEO Susan L. Solomon discussed "Harnessing patient data using stem cells to power precision medicine" during her co-located keynote plenary talk at the Cord Blood World Europe, World Advanced Therapies & Regenerative Medicine Congress 2017, and the World Precision Medicine Congress 2017 conferences in London, UK. Following the plenary discussion, Ms. Solomon joined a panel to explore "The Future of Medicine: A Conversation" with Dr. Ian Campbell, Director for Health and Life Sciences, Innovate UK; Dr. Joanne Kurtzberg, Director, Carolinas Cord Blood Bank, Duke University; and Dr. Patrick Keohane, Chief Medical Officer, BenevolentAI.
 
The annual New York BIO conference in Manhattan also featured Ms. Solomon on a panel exploring the success of "Research Foundations with Innovative Business Models in New York" alongside Annette Bakker of the Children's Tumor Foundation, Michael Batten of the T1D Fund and JDRF, Sohini Chowdhury of The Michael J. Fox Foundation for Parkinson’s Research, Lara Sullivan of Pfizer, and the New York City Economic Development Corporation.
 
 
 
NYSCF Innovator Maps Neural Circuit for Fly Navigation
NYSCF Innovator Maps Neural Circuit for Fly Navigation

To successfully exist, many animals keep track of their angular heading, or directionality, over time as they navigate their environments; however, the brain architecture enabling this capability has never been mapped in any species until now. Using a fly animal model, NYSCF – Robertson Neuroscience Investigator Alumnus Dr. Gaby Maimon and a team at The Rockefeller University successfully mapped two classes of shifting neurons, clockwise- and anticlockwise-shifting, each with two subtypes, whose wiring and physiology provide a means to rotate an angular heading estimate based on the fly’s angular velocity.

Importantly, the features of this biological circuit are similar to proposed computation models of head-direction cells in rodents. Therefore, this research may shed light on neural systems integration in a wide variety of species.

 

Read the paper in Nature >>

NYSCF Innovator Improves Neuron Derivation from Stem Cells
NYSCF Innovator Improves Neuron Derivation from Stem Cells

Creating consistent groups of mature neurons from stem cells remains challenging in the lab. NYSCF – Robertson Stem Cell Investigator and NYSCF – Robertson Stem Cell Prize recipient Dr. Marius Wernig and his team from Stanford University developed a method to consistently derive GABAergic neurons directly from human stem cells with high levels of maturity. The scientists used lineage-specific transcription factor programming to achieve these remarkable results. 

Published in Nature Methods, this work represents an important step towards enabling the study of diseases affecting these neurons and their signaling ability.

 

Read the paper in Nature Methods >>

  • NYSCF Press Releases

    A Robust, High-Throughput Protocol for Deriving Microglia From Human Stem Cells
    NYSCF Research Institute scientists have developed a robust, efficient method for deriving microglia, the immune cells of the brain, from human stem cells. Microglia are…

    Read more »
    NYSCF Opens New Research Institute and Headquarters in Manhattan
    NYSCF officially opened its new state-of-the-art Research Institute and headquarters in Manhattan. The expanded NYSCF Research Institute will allow scientists to conduct the most advanced…

    Read more »
    Partnership Results in the Availability of Fully-Sequenced Stem Cell Lines
    A collaboration beginning in 2013 between the NYSCF Research Institute and the Personal Genome Project (PGP) resulted in the availability of a unique new stem…

    Read more »
    Feng Zhang Receives 2016 NYSCF – Robertson Stem Cell Prize
    NYSCF announced today that Feng Zhang, PhD, is the 2016 recipient of the NYSCF – Robertson Stem Cell Prize for his pioneering advances to edit…

    Read more »
    NYSCF Announces the Six Members of the 2016 Class of NYSCF - Robertson Investigators
    NYSCF announced the 2016 class of NYSCF – Robertson Investigators, welcoming six of the most talented stem cell researchers and neuroscientists from around the world…

    Read more »
  • News
    You are here: News