NYSCF – Robertson Neuroscience Investigator Dr. Ed Boyden and his team at MIT Media Lab published their latest work advancing and improving their revolutionary imaging technique: expansion microscopy. The research, published in Nature Methods, describes an advance on standard expansion microscopy, increasing magnification by 20x the sample size.
The expansion microscopy technique revolutionized imaging by physically expanding biological specimens while maintaining their characteristics and proportions. Standard expansion microscopy begins by embedding and homogenizing a specimen in a dense polymer gel. The specimen is then physically expanded by 4.5x its starting size by swelling the gel. This technique enables scientists to study the biological structures of minute specimens with unheard of clarity, using standard microscopes and magnification.
The new process, dubbed iterative expansion microscopy, puts the sample through an additional expansion enabling nanometer resolution imaging of cells and tissues on conventional microscopes.
NYSCF – Robertson Neuroscience Investigator Dr. Lisa Giocomo and a team at Stanford University published their recent work in Neuron investigating how navigation works in the brain. Grid cells, commonly known as the GPS of the brain, along with border, head direction, and speed cells comprise the four main types of cells in the navigation system in mammalian brains. The scientists found that the navigation system and the cells that comprise it are much more complex and multifaceted than previously assumed. Instead of distinct cell types, they found that many cells displayed characteristics of multiple cell types and even the flexibility to display traits of one type followed by the traits of another.
This work upends the assumption that our navigational brain function can be mapped with a mathematical model. Much more research is needed to fully understand the navigation process, including a fundamental reassessment of the mechanisms in play.
President Donald Trump's proposed 2018 budget cuts $5.8 billion from the National Institutes of Health (NIH), about 20% of its current budget. While these numbers represent a request to Congress and not a final agreement, the cuts are a dramatic statement against science as a priority for the administration and for our country.
These cuts, if implemented, may have a greater negative impact on the stem cell research field than the restrictions implemented by former President Bush. Ongoing NIH funding is critical to all biomedical research, including ours at The New York Stem Cell Foundation. Cutting these funds is a major risk for all research, and threatens to slow down or stop potentially lifesaving experiments while also put at risk the jobs of many scientists across the country.
The President has also proposed significant budget cuts to the NIH and other scientific agencies for the remainder of this year’s budget. These drastic measures would be a major step back for the advancement of science and medicine in the United States.
Politico spoke with NYSCF CEO Susan L. Solomon about the proposed cuts, read the story here (firewalled) >>